COURSE OVERVIEW
Who is this course for?
Users of GC-MS equipment, or anyone interested in structural elucidation by GC-MS.
Previous Knowledge
A good working knowledge of the technique is required. A basic knowledge of organic chemistry is advantageous but not essential.
What you will learn
- How to optimise instrument and method parameters to obtain high-quality spectral data
- Ionisation and fragmentation mechanisms in GC-MS
- The logical evolution of an ‘Interpretation Toolkit & with a multitude of practice spectra with worked solution on which to practise new skills
- The fundamental spectral interpretation toolkit, and how to use it when confronted with the mass spectrum of an unknown
COURSE OUTLINE
Application Areas of GC-MS
- Environmental pollutant analysis
- Drug testing and toxicology
- Food safety and pesticide residue detection
- Metabolomics and biomarker discovery
Troubleshooting Common GC-MS Issues
- Poor chromatographic resolution& peak tailing
- Ion suppression & detector saturation
- Contaminants, ghost peaks, and baseline drift
Method Development & Validation
- Developing robust GC-MS methods
- Validation parameters (precision, accuracy, sensitivity, linearity)
- Regulatory guidelines (EPA, FDA, ICH, forensic standards)
Q&A and Closing Discussion
- Summary of Key Concepts
- Open Discussion on Challenges Faced in GC-MS
- Resources for Further Learning